Happy Sisters Supplement
- Addresses root causes of fibrocystic breasts, benign breast lumps and cysts, and breast pain
- Benefits estrogen balance, lymphatic system, and inflammatory responses
- Softgels, 60-day supply (2 months)
Recommended use: Take 1 softgel once a day, with food. Can be taken in the morning or evening.
Borage (Borago officinalis) Oil, Yerba santa Extract (Eriodictyon californicum)(whole plant), Andographis Extract (Andrographis paniculata)(aerial parts), Red root Extract (Ceanothus americanus)(whole plant), Red clover Extract (Trifolium pratense)(leaf), Magnesium Bisglycinate, Calcium D-Glucarate, Diindolylmethane (DIM)
COMT methylation protective against undesirable estrogen metabolites https://pubmed.ncbi.nlm.nih.gov/11606384/
Magnesium, PMS, mastalgia https://pubmed.ncbi.nlm.nih.gov/6684167/
Magnesium: physiology and pharmacology https://www.bjanaesthesia.org/article/S0007-0912(17)38397-6/pdf
Magnesium glycinate and myometrial relaxation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071389/pdf/nutrients-12-00573.pdf
Article on estrogen metabolism, COMT, and magnesium by a physician / biochemist https://www.drlaurendeville.com/articles/estrogen-detoxification/
Calcium D-glucarate monograph - https://altmedrev.com/wp-content/uploads/2019/02/v7-4-336.pdf
Calcium D-glucarate as a beta-glucuronidase inhibitor https://pubmed.ncbi.nlm.nih.gov/18772850/
Article on Calcium D-glucarate and estrogen metabolism, NMD journal https://ndnr.com/endocrinology/estrogen-dominance-in-women/
Article on Calcium D-glucarate from a functional medicine physician / biochemist https://drbrighten.com/benefits-of-calcium-d-glucarate/
Composition and physiological activities of Borage seed oil - https://pubmed.ncbi.nlm.nih.gov/25312125/
GLA and cyclic mastalgia https://pubmed.ncbi.nlm.nih.gov/18296341/
GLA, eicosanoids, and inflammation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975646/pdf/nihms781789.pdf
Borage oil and inflammatory gene expression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708836/pdf/zbc15400.pdf
GLA and PMS-associated inflammation / dysmenorrhea https://pubmed.ncbi.nlm.nih.gov/18296341/
Black seed oil for cyclic mastalgia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820470/pdf/2093-6966-v22-n03-131.pdf
Black seed oil as an anti-inflammatory agent https://pubmed.ncbi.nlm.nih.gov/33559935/
Nigella sativa: monograph https://www.phytojournal.com/archives/2015/vol4issue4/PartB/4-3-79.pdf
Black seed oil for breast health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460502/pdf/medicines-07-00047.pdf and https://pubmed.ncbi.nlm.nih.gov/26964971/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921197/pdf/main.pdf
See the extensive clinical monograph on Phytolacca in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 795-798.
Phytolacca in King’s American Dispensatory, the standard Eclectic medical publication of 1898 https://www.henriettes-herb.com/eclectic/kings/phytolacca.html
Ruth Trickey (with practitioners from the Melbourne Holistic Health Group), respected midwife and herbalist, mentions the use of Poke for mastalgia in her classic Women, Hormones & the Menstrual Cycle, 3rd Ed., Trickey Enterprises (Victoria) Pty, Limited; 2011.
Bioactive triterpene saponins from Phytolacca americana https://pubmed.ncbi.nlm.nih.gov/33002830/
Dr. Aviva Romm mentions topical Phytolacca for benign breast disease in Botanical Medicine for Women’s Health (p. 595), Churchill Livingstone; 2nd Ed.; 2017.
Effective medicinal plants for cyclic mastalgia, a review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820470/
Topical application of St. John’s Wort https://pubmed.ncbi.nlm.nih.gov/24214835/
Anti-inflammatory mechanisms of Hypericum oil https://pubmed.ncbi.nlm.nih.gov/24993886/
Cell-growth regulating effects of the oil-soluble constituents https://pubmed.ncbi.nlm.nih.gov/33379141/
See the extensive clinical monograph on Hypericum in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 826-860.
Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast Journal. 2009;15:510–4. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/19614907
American Herbal Pharmacopoeia (AHP) monograph on Trifolium http://pharmaguri.co.il/_Uploads/dbsAttachedFiles/AHPTrifoliumMonograph.pdf
Review – pharmacology of the main isoflavonoid in Trifolium, Biochanin A https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639423/pdf/fphar-10-00793.pdf
Trifolium’s potential as a complementary therapy in breast cancer (apoptotic, antioxidant, anti-inflammatory) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455927/
Pharmacological and therapeutic properties of Red Clover 2021 https://pubmed.ncbi.nlm.nih.gov/34392659/
Isoflavones (Trifolium constituent) and mastalgia, clinical trial https://pubmed.ncbi.nlm.nih.gov/14965665/
Clinical actions of Red Clover https://restorativemedicine.org/library/monographs/red-clover/
Anti-inflammatory activity of Andrographis and andrographolide https://pubmed.ncbi.nlm.nih.gov/25888070/
Anti-inflammatory diterpenoid lactones in Andrographis https://pubmed.ncbi.nlm.nih.gov/31357563/
Andrographis review: ethnobotany, phytochemistry, pharmacology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408759/pdf/TSWJ2014-274905.pdf
See the extensive clinical monograph on Andrographis in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 360-372.
See Discover Andrographis by Alexander Panossian, Ph.D. Detailed monograph/book. https://www.academia.edu/40480219/DISCOVER_ANDROGRAPHIS
DO YOU SHIP TO CANADA, THE UK, AUSTRALIA OR OTHER COUNTRIES?
Unfortunately, at this point we only ship to the United States. This is due to the ever-evolving international laws surrounding supplements.
There are forwarding companies like MyUS.com, that will forward orders to you in your country for a fee.
In this case, it is the customer's responsibility to find out in advance if the supplement in question is legal in their country. For example, Progesterone and DHEA are not legal to ship into Canada (Canada classifies bio-identical hormones as drugs so they can only be prescribed by a doctor or naturopath).
We have had customers successfully ship their supplements abroad using MyUS.com, however we have only limited experience with this service.
WHY DOES SHIPPING COST $11.45?
For small businesses like ours, the shipping fee covers the very real costs of getting your order to you: shipping, handling, packaging, warehousing, insurances, and fairly compensating all the people involved along the way. We do our best to keep this shipping cost as low as possible, and offer FREE shipping for orders $97 and above.
WHY DOES MY SUBSCRIPTION ORDER INCLUDE $11.45 SHIPPING?
If you set up a subscription order and notice that you are being charged shipping, it could be due to one of these reasons:
1. Your order value is under $97
2. Your initial order qualifies for free shipping, but the order frequency on your subscriptions is different ( 1 product is set to ship every month, the other is set to ship every 2 months).
*The system automatically splits this kind of order into 2 separate shipments.
In this case it is more economical to set up one subscription every 2 months, and to increase your quantity to 2 units of the supplement that you consume monthly.
For example: 2 Vitamin B6 + 1 Essential Omegas every 2 months = free shipping.
Please email us at email@example.com if you would like some help managing your subscriptions.
How we make things to be delivered directly to you
All our products are rooted in science. No BS, just clean and honest ingredients that work.
No greenwashing means that we don't use misleading marketing to make our products seem more green or eco-friendly. Our products really are as natural as it gets.
We work hard to bring you products that are safe and effective. The top offenders we never invite to the party: GMOs, hormone disruptors, gluten, soy, and dairy.
Our manufacturing facilities are GMP compliant, which means every product is carefully tested. Our products are proudly made in the US and Canada.
Many of our products use botanicals inspired by ancient herbal traditions from around the world.
Our ingredients work synergistically, amplifying each other. We transform them into meaningful products that make a difference for your body and spirit.