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ProgestPure Cream

$69.99
$419.94
$69.99 - $419.94
$419.94
$69.99
$69.99 - $377.95
$69.99
  • Quick absorbing bioidentical progesterone cream
  • 25 mg progesterone per serving
  • No fillers, perfumes, phthalates, or mineral oils
  • Can ease symptoms of peri- and menopause
  • 60-day supply (2 months)
  • FREE Progesterone Essentials checklist PDF
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Deliver Every:
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“ProgestPure has been a life-changing supplement to address low levels of progesterone and possible Estrogen Dominance. Night and day difference. Thank you!”
– CARRIE W., USA – VERIFIED BUYER
What It Does

How ProgestPure Cream can help hormones

  • Reduces hot flashes and night sweats
  • Supports deeper and more restful sleep
  • Reduces PMS symptoms, bloating, water retention, and mood swings
  • Restores a healthy menstrual cycle (less bleeding, shorter days)
  • Restores ovulation and a healthy luteal phase (women in peri-menopause often experience shortened luteal phase)
  • Reduces uterine fibroids and endometriosis
  • Reduces pelvic pain
  • Increases thyroid function (shown to increase free thyroxine)
  • Reduces breast lumps
  • Relieves pain in fibrocystic breasts
  • Inhibits mast cells releasing histamine
  • Enhances mood
  • Relieves anxiety

How ProgestPure Cream may support overall health

  • Improvement of bone health and even osteoporosis (by having an osteoblastic effect)
  • Improvement of quality of sleep (length and depth)
  • Reducing inflammatory responses in the body
  • Brain function improvement
  • Support in TBI cases

Progesterone After 45

Progesterone starts to drop dramatically the moment we turn 45. In fact, in women who stop ovulating (due to age), while estrogen drops by 60%, progesterone can drop as much as 90%. This is why women might need progesterone as the first line of support, before estrogen.

Symptoms of Progesterone Deficiency

  • Hot flashes and night sweats
  • Insomnia and mid night waking
  • Fertility or menstrual problems
  • PMS or PMDD
  • Anxiety and restlessness
  • Irritability and nervousness
  • Low mood and depression, especially around ovulation and pre-period
  • Mood swings
  • Weight gain and cellulite, especially around the thighs and buttocks
  • Fluid retention – your fingers and toes swell up
  • Brain fog
  • Sagging skin
  • Low thyroid
  • Pain and inflammation
  • Osteoporosis
  • Excessive menstruation
  • Hypersensitivity
  • Migraine headaches before cycles
  • Decreased libido
  • Decreased HDL (“good” cholesterol)
DID YOU KNOW?
Have you always been a good sleeper and now you just can't fall or stay asleep? It could be low progesterone.

After 45, our progesterone levels start dropping and can "suddenly" cause hot flashes, poor sleep, short periods, anxiety, and poor bone health.

The efficacy and quick absorption of ProgestPure Cream have made it one of the most helpful and therefore popular products in our community. This progesterone cream contains no parabens, mineral oils, fragrances, phthalates, or harsh preservatives.

Magdalena Wszelaki, Wellena Founder

Real People. Real Results.

Where to apply progesterone for maximum effectiveness?

How Much Progesterone You Should Use and Where to Apply It

It will depend on how low and symptomatic you are, your diet, and stress levels (stress steals progesterone). We recommend to start slow and slowly dose up.

If you choose to use ProgestPure Cream, start with four pumps which will give you 25 mg of bioidentical progesterone. You can double that (by doing it twice a day) to 50 mg per day if symptoms don’t improve. If you're generally sensitive, start with as little as one pump. Rotate the areas of application using fast-release areas and slow-release areas - see graphic on the right.

Another way to dose is to use your body weight.

Women under 150 lbs: start with 20 to 30 mg of bioidentical progesterone.

Women over 150 lbs: start with 40 to 50 mg of bioidentical progesterone.

If you want to try a higher dosage, I recommend working with a skilled functional practitioner who knows the ins and outs of bioidentical hormones and tests your levels.

This Product Works Best With

Wise Women's Balance Helps to relieve normal menopausal discomfort $69.99
DIM - Last Chance Supports metabolism of estrogen in Phase I liver detoxification $29.39
Magnesium Replenish Highly bioavailable form of magnesium, fastest to replenish low levels $42.99
How to use
4 pumps per day

Recommended use: Apply 4 pumps (25 mg Progesterone USP) one time per day to smooth skin areas such as the wrists, inner arms or thighs, throat, neck, abdomen or chest, or as directed by your healthcare provider. For optimal use, rotate the areas of application. Use the above guide on fast- and slow-release areas for guidance.

For women finished with menstruation (or nearly finished with menstruation):

Women going through peri-menopause, menopause, and post-menopause; who suffer from sleep disruption, hot flashes, or night sweats, can use topical progesterone for up to 25 days out of a 30-day calendar, with 5-7 days off, or as recommended by your healthcare provider.

For menstruating women:

Menstruating women are advised to use topical progesterone 5 to 7 days after the first day of your period and continue until the next period begins. Day 1 is the first day of your menstrual bleed. If your period is irregular, start using topical progesterone 7 days after you begin a period and teach your body to learn a new cycle. Stop whenever your period comes back again, and repeat, or apply as recommended by your healthcare provider.


Warning: This product can expose you to progesterone, a chemical known to the State of California to cause cancer. For more information go to www.P65warnings.ca.gov.
Our Ingredients

Purified Water, Micronized Progesterone (from Wild Yam), Glycerin, Aloe Vera Gel, Caprylic/Capric Triglyceride, Stearic Acid, MSM (Methylsulfonylmethane), Olive Oil, Coconut Oil, Isopropyl Palmitate, Stearyl Alcohol, Vitamin E, Radish Extract (Natural Preservative), Carbomer, Allantoin, Shea Butter, Sunflower Lecithin, Sodium Bicarbonate, Acacia Gum (Wild Crafted), Proprietary Blend of Essential Oils and Herbs

Quality Check

A quality topical progesterone should be FREE of:
  • Parabens
  • Mineral oil
  • Phthalates (fragrances)
  • Petroleum
  • Synthetic progesterone (progestins)

Reviews

Customer Reviews
4.7 Based on 172 Reviews
5 ★
83% 
142
4 ★
9% 
15
3 ★
8% 
15
2 ★
0% 
0
1 ★
0% 
0
Customer Photos
ProgestPure Cream - Customer Photo From Anonymousi
ProgestPure Cream - Customer Photo From Anonymousi
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  • cream
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  • progesterone
  • menopause
  • hormones
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JH
03/21/2025
Janice H.
United States

I use religiously at night!

Very helpful in easing sleep issues with perimenopause! I have 2 autoimmune disorders and have to be careful with what supplements I use and I do highly recommend! It is not an end all cure! You must be doing other things with your diet, removing toxins, etc to be able to get optimal results! So don’t expect a magic cream if other things in your lifestyle are triggering your hormones!

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A
03/14/2025
Anonymous
United States

Very Good Product

I had a hysterectomy about 20 years ago. So I had all the menopausal symptoms develop. Each night, I use 4-5 pumps of this natural cream. I rotate the places where I put the cream. My sleep is so much better. Sometimes, I will even use 1-2 pumps in the morning for my nervous system. I love this cream. I highly recommend it!

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A
02/28/2025
Anonymous
United States

ProgestPure Cream is the BEST!

I started using this product to help with night sweats, ovulation headaches and mid-cycle spotting and it has done just that! I am also sleeping throughout the night! I will definitely keep ordering it!

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A
01/30/2025
Anonymous
United States

Progestpure Cream

I love this product! I use it nightly and it has really helped with my night sweats and also has improved my sleep.

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S
01/19/2025
Sangitha
United States

Excellent

Helps me sleep well. I have tried a few different brands and this one is the best in terms of quality absorption and effectiveness, thank you Wellena!

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Frequently Asked Questions

For menstruating women, ProgestPure Cream supports progesterone levels within a normal range and may increase the likelihood of a healthy cycle and fertility. For peri-, menopausal, and post-menopausal women, ProgestPure Cream supports progesterone levels in the body and may help make this significant life change more pleasant.
The recommended dose is 20 to 30 mg (four pumps of ProgestPure Cream), once or twice per day, or as recommended by your health practitioner.
Women going through peri-menopause, menopause, and post-menopause; who suffer from sleep disruption, hot flashes, or night sweats, can use topical progesterone for up to 25 days out of a 30-day calendar, with 5-7 days off, or as recommended by your healthcare provider. Menstruating women are advised to use topical progesterone 5 to 7 days after the first day of your period and continue until the next period begins. Day 1 is the first day of your menstrual bleed. If your period is irregular, start using topical progesterone 7 days after you begin a period and teach your body to learn a new cycle. Stop whenever your period comes back again, and repeat, or apply as recommended by your healthcare provider.
Our topical progesterone cream provides 25 mg of bioidentical progesterone in four pumps.
ProgestPure Cream can be used to support progesterone levels to improve hormonal balance. If you experience irregular or short periods, low libido, migraines or headaches, hot flashes, sleep issues, anxiety, spotting, period pain or vaginal dryness, ProgestPure Cream could be an option to consider.
The bioidentical progesterone is derived from yams and is then modified, so the progesterone molecule resembles a human progesterone molecule.
No, this cream was designed for skin application, not vaginal application, as the vulva contains no progesterone receptors.
No, this product is not meant for use on the face. Topical progesterone can increase sebum and oil production so it can cause some sensitive women to have more breakouts or increased oily skin.
Yes, In fact, bioidentical progesterone is recommended for use after a hysterectomy even though most conventional doctors only prescribe estrogen. Functional endocrinology recommends for women with full or partial hysterectomy to supplement with both estrogen and progesterone.
Yes. Progesterone supplementation during postmenopause can be key to reducing or minimizing uncomfortable post-menopause symptoms.

Putting topical progesterone on your body allows it to bypass digestion and the liver which is beneficial for two reasons. One, you don’t tax your digestion and liver with yet another compound to be absorbed and metabolized. Two, if your gut and liver aren’t functioning optimally, you are running the risk of your body breaking down progesterone into “dirty” progesterone metabolites, which can be harmful.

Furthermore, oral progesterone is largely converted to allopregnanolone on its first pass through the liver. This isn’t the best choice as a progesterone replacement therapy, because allopregnanolone attaches to GABA receptors, creating anxiolytic (anti-anxiety) and somniferous (induces sleep) effects. Oral progesterone does not offer all the other benefits of progesterone (described above).

For these reasons, I recommend progesterone in a topical form, not an oral form.

No, ProgestPure Cream does not contain soy.
Yes, men can take bioidentical progesterone in far smaller amounts and we recommend working under the supervision of a functional doctor.
Start slow and low, and slowly increase the amount used over time. For example, start with one pump of 6.25 mg once a day for 3 to 5 days and see how you do, then titrate up to 12.5 mg (2 pumps) for 3 to 5 days. Slowly increase to using 25 mg or 4 pumps.
Thin skin areas, such as wrists, inner arms or thighs, throat, neck, abdomen or chest, or as directed by a health care practitioner. ProgestPure Cream is not designed to be applied to the face or the vaginal area.
We ensure purity and potency for 2 years after the date on the bottle.
Yes, this is both vegan and vegetarian.
The essential oils in ProgestPure Cream are sourced from herbs and spices, including rosemary, star anise, and cinnamon. The oils are bound onto wild-crafted Acacia gum and have been either steam distilled or extracted with sub-critical CO2. They are non-GMO and are used as a natural preservative rather than harsh chemical preservatives typically found in a wide range of products.
We have found the scent to be very minimal, and don't notice an essential oil smell at all for those who are very sensitive. To us, it has the faintest clean smell.
The short answer: no. Firstly, progesterone starts to drop dramatically the moment we hit 40-45. In fact, in women who stop ovulating (due to age), while estrogen drops by 60%, progesterone can drop as much as 80 to 100%. Further progesterone depletion can happen with stress, infections, chronic inflammation, frequent travel, hypothyroidism, and rapid aging. Women who are over 40 and stressed (hello 👋), or identify with any of the above, will experience the most relief from topical progesterone.

This is an airless and tubeless package, and sometimes with the first pump, it requires a bit of finesse to get it moving.

Please use the steps below to correct the pumping issue with the airless packaging:

1) Please ensure the lid/pump is secured tightly on the bottle.

2) Turn the bottle upside down and shake. This will help move the product towards the top of the pump (similar to turning a condiment bottle such as mustard upside down to get the product to the top).

3) Try to pump the bottle while holding it upside down. Continue to shake the product to the top of the pump. Use slow firm pumps. This will help to get the air out of the bottle.

*Note: Pumping too quickly will not create the suction it requires.

Shanafelt, Tait D., et al. "Pathophysiology and Treatment of Hot Flashes." Mayo Clinic Proceedings. November 2002.

Seifert-Klauss, Vanadin and Prior, Jerilynn C. “Progesterone and Bone: Actions Promoting Bone Health in Women.” National Library of Medicine. October 2010. [PMID: 21052538]

Prior, J C. “Progesterone for the prevention and treatment of osteoporosis in women.” National Library of Medicine. July 2018. [PMID: 29962257]

“Premenstrual syndrome: Treatment for PMS.” Institute for Quality and Efficiency in Health Care (IQWiG). June 2017.

Spark MJ, Willis J. “Systematic review of progesterone use by midlife and menopausal women.” Maturitas. July 2012. [PMID: 22541358]

Kim, J. Julie, et al. “Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer.” Endocrine Reviews, Volume 34, Issue 1, 1 February 2013.

Stratton, Pamela and Berkley, Karen J. “Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Human Reproduction Update. November 23, 2010.

Sathi, P., et al. “Progesterone therapy increases free thyroxine levels--data from a randomized placebo-controlled 12-week hot flush trial.” August 2013. [PMID: 23252963]

Formby, B., and Wiley, T S. “Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53.” November and December, 1998. [PMID: 9846203]

Huang, Yeqian, et al. “Effects of sex hormones on survival of peritoneal mesothelioma.” June 2015. [PMID: 26111523]

Hill, MJ, et al. “Progesterone luteal support after ovulation induction and intrauterine insemination: a systematic review and meta-analysis.” Fertility and Sterility. 2013.

Shipping
FAQs

Frequently Asked Questions

For menstruating women, ProgestPure Cream supports progesterone levels within a normal range and may increase the likelihood of a healthy cycle and fertility. For peri-, menopausal, and post-menopausal women, ProgestPure Cream supports progesterone levels in the body and may help make this significant life change more pleasant.
The recommended dose is 20 to 30 mg (four pumps of ProgestPure Cream), once or twice per day, or as recommended by your health practitioner.
Women going through peri-menopause, menopause, and post-menopause; who suffer from sleep disruption, hot flashes, or night sweats, can use topical progesterone for up to 25 days out of a 30-day calendar, with 5-7 days off, or as recommended by your healthcare provider. Menstruating women are advised to use topical progesterone 5 to 7 days after the first day of your period and continue until the next period begins. Day 1 is the first day of your menstrual bleed. If your period is irregular, start using topical progesterone 7 days after you begin a period and teach your body to learn a new cycle. Stop whenever your period comes back again, and repeat, or apply as recommended by your healthcare provider.
Our topical progesterone cream provides 25 mg of bioidentical progesterone in four pumps.
ProgestPure Cream can be used to support progesterone levels to improve hormonal balance. If you experience irregular or short periods, low libido, migraines or headaches, hot flashes, sleep issues, anxiety, spotting, period pain or vaginal dryness, ProgestPure Cream could be an option to consider.
The bioidentical progesterone is derived from yams and is then modified, so the progesterone molecule resembles a human progesterone molecule.
No, this cream was designed for skin application, not vaginal application, as the vulva contains no progesterone receptors.
No, this product is not meant for use on the face. Topical progesterone can increase sebum and oil production so it can cause some sensitive women to have more breakouts or increased oily skin.
Yes, In fact, bioidentical progesterone is recommended for use after a hysterectomy even though most conventional doctors only prescribe estrogen. Functional endocrinology recommends for women with full or partial hysterectomy to supplement with both estrogen and progesterone.
Yes. Progesterone supplementation during postmenopause can be key to reducing or minimizing uncomfortable post-menopause symptoms.

Putting topical progesterone on your body allows it to bypass digestion and the liver which is beneficial for two reasons. One, you don’t tax your digestion and liver with yet another compound to be absorbed and metabolized. Two, if your gut and liver aren’t functioning optimally, you are running the risk of your body breaking down progesterone into “dirty” progesterone metabolites, which can be harmful.

Furthermore, oral progesterone is largely converted to allopregnanolone on its first pass through the liver. This isn’t the best choice as a progesterone replacement therapy, because allopregnanolone attaches to GABA receptors, creating anxiolytic (anti-anxiety) and somniferous (induces sleep) effects. Oral progesterone does not offer all the other benefits of progesterone (described above).

For these reasons, I recommend progesterone in a topical form, not an oral form.

No, ProgestPure Cream does not contain soy.
Yes, men can take bioidentical progesterone in far smaller amounts and we recommend working under the supervision of a functional doctor.
Start slow and low, and slowly increase the amount used over time. For example, start with one pump of 6.25 mg once a day for 3 to 5 days and see how you do, then titrate up to 12.5 mg (2 pumps) for 3 to 5 days. Slowly increase to using 25 mg or 4 pumps.
Thin skin areas, such as wrists, inner arms or thighs, throat, neck, abdomen or chest, or as directed by a health care practitioner. ProgestPure Cream is not designed to be applied to the face or the vaginal area.
We ensure purity and potency for 2 years after the date on the bottle.
Yes, this is both vegan and vegetarian.
The essential oils in ProgestPure Cream are sourced from herbs and spices, including rosemary, star anise, and cinnamon. The oils are bound onto wild-crafted Acacia gum and have been either steam distilled or extracted with sub-critical CO2. They are non-GMO and are used as a natural preservative rather than harsh chemical preservatives typically found in a wide range of products.
We have found the scent to be very minimal, and don't notice an essential oil smell at all for those who are very sensitive. To us, it has the faintest clean smell.
The short answer: no. Firstly, progesterone starts to drop dramatically the moment we hit 40-45. In fact, in women who stop ovulating (due to age), while estrogen drops by 60%, progesterone can drop as much as 80 to 100%. Further progesterone depletion can happen with stress, infections, chronic inflammation, frequent travel, hypothyroidism, and rapid aging. Women who are over 40 and stressed (hello 👋), or identify with any of the above, will experience the most relief from topical progesterone.

This is an airless and tubeless package, and sometimes with the first pump, it requires a bit of finesse to get it moving.

Please use the steps below to correct the pumping issue with the airless packaging:

1) Please ensure the lid/pump is secured tightly on the bottle.

2) Turn the bottle upside down and shake. This will help move the product towards the top of the pump (similar to turning a condiment bottle such as mustard upside down to get the product to the top).

3) Try to pump the bottle while holding it upside down. Continue to shake the product to the top of the pump. Use slow firm pumps. This will help to get the air out of the bottle.

*Note: Pumping too quickly will not create the suction it requires.

How We Make Things

How we make things to be delivered directly to you

Science. Research. Facts.

All our products are rooted in science. No BS, just clean and honest ingredients that work.

We don’t greenwash. Ever.

No greenwashing means that we don't use misleading marketing to make our products seem more green or eco-friendly. Our products really are as natural as it gets.

If it’s not squeaky clean, it’s out.

We work hard to bring you products that are safe and effective. The top offenders we never invite to the party: GMOs, hormone disruptors, gluten, soy, and dairy.

Rigorously tested

Our manufacturing facilities are GMP compliant, which means every product is carefully tested. Our products are proudly made in the US and Canada.

Time-honored traditions

Many of our products use botanicals inspired by ancient herbal traditions from around the world.

1+1 = 5

Our ingredients work synergistically, amplifying each other. We transform them into meaningful products that make a difference for your body and spirit.

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