Happy Sisters Supplement

Original price $69.99 - Original price $377.95
Original price
$69.99 - $377.95
Current price $69.99
  • Addresses root causes of fibrocystic breasts, benign breast lumps and cysts, and breast pain
  • Benefits estrogen balance, lymphatic system, and inflammatory responses
  • Softgels, 60-day supply (2 months)
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We understand the overwhelming fear of finding a breast lump, skipping a workout due to breast pain, or not being able to put on a bra because our "sisters" hurt so bad.

How Happy Sisters Supplement can support breast health:

  • May reduce breast pain
  • May reduce fibrocystic breast lumps
  • May reduce inflammatory responses in the breast
  • Supports the lymphatic system

The herbs and oils in this formula may help:

  • Borage Oil - Reduce breast tenderness and swelling
  • Yerba Santa Extract - Clear excess estrogen
  • Andrographis Extract - Support detoxification and hormone metabolism
  • Red Root Extract - Relieve sore, swollen, lumpy breasts
  • Red Clover Extract - Balance Estrogen Dominance

As a hormone nutritionist and herbalist, I’ve struggled with fibrocystic breasts and benign lumps most of my life. — Magdalena, founder of Wellena and creator of Happy Sisters

Featured Ingredients

Yerba Santa Extract Clears excess estrogen
Andrographis Extract Supports detoxification and hormone metabolism
Borage Seed Oil Reduces breast tenderness and swelling
Red Root Extract Relieves sore, swollen, lumpy breasts
"I’m all pain-free and finally have peace of mind"
“Went for my mammogram... And it said that both breasts were completely clear, so the cyst was gone. And I have to believe that the cream did it."
"This is a game changer for women who experience breast pain or fibrocystic breasts."
How to take the supplement
1 Softgel a day

Recommended use: Take 1 softgel once a day, with food. Can be taken in the morning or evening.

Our Ingredients

Borage (Borago officinalis) Oil, Yerba santa Extract (Eriodictyon californicum)(whole plant), Andographis Extract (Andrographis paniculata)(aerial parts), Red root Extract (Ceanothus americanus)(whole plant), Red clover Extract (Trifolium pratense)(leaf), Magnesium Bisglycinate, Calcium D-Glucarate, Diindolylmethane (DIM)

Other Ingredients: Sunflower Lecithin, Yellow Beeswax, Sunflower Seed (Helianthus) Oil; Gelatin, Purified Water, Glycerin, Annato Extract (Softgel Ingredients)

Happy Sisters Supplement works best with:

Happy Sisters Cream Thoughtfully formulated daily topical cream to reduce breast pain, soothe inflammation, and shrink lumps and cysts. $19.99
ProgestPure Cream Highly bioavailable cream provides 25 mg of bioidentical progesterone per serving $69.99
Magnesium Replenish Highly bioavailable form of magnesium, fastest to replenish low levels $42.99

Quality Check

A quality supplement should:
  • contain herbs that have been 3rd party tested for efficacy
  • contain no fillers and additives
  • be made in a GMP facility


COMT methylation protective against undesirable estrogen metabolites https://pubmed.ncbi.nlm.nih.gov/11606384/

Magnesium, PMS, mastalgia https://pubmed.ncbi.nlm.nih.gov/6684167/

Magnesium: physiology and pharmacology https://www.bjanaesthesia.org/article/S0007-0912(17)38397-6/pdf

Magnesium glycinate and myometrial relaxation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071389/pdf/nutrients-12-00573.pdf

Article on estrogen metabolism, COMT, and magnesium by a physician / biochemist https://www.drlaurendeville.com/articles/estrogen-detoxification/

Calcium D-glucarate monograph - https://altmedrev.com/wp-content/uploads/2019/02/v7-4-336.pdf

Calcium D-glucarate as a beta-glucuronidase inhibitor https://pubmed.ncbi.nlm.nih.gov/18772850/

Article on Calcium D-glucarate and estrogen metabolism, NMD journal https://ndnr.com/endocrinology/estrogen-dominance-in-women/

Article on Calcium D-glucarate from a functional medicine physician / biochemist https://drbrighten.com/benefits-of-calcium-d-glucarate/

Composition and physiological activities of Borage seed oil - https://pubmed.ncbi.nlm.nih.gov/25312125/

GLA and cyclic mastalgia https://pubmed.ncbi.nlm.nih.gov/18296341/

GLA, eicosanoids, and inflammation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975646/pdf/nihms781789.pdf

Borage oil and inflammatory gene expression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708836/pdf/zbc15400.pdf

GLA and PMS-associated inflammation / dysmenorrhea https://pubmed.ncbi.nlm.nih.gov/18296341/

Black seed oil for cyclic mastalgia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820470/pdf/2093-6966-v22-n03-131.pdf

Black seed oil as an anti-inflammatory agent https://pubmed.ncbi.nlm.nih.gov/33559935/

Nigella sativa: monograph https://www.phytojournal.com/archives/2015/vol4issue4/PartB/4-3-79.pdf

Black seed oil for breast health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460502/pdf/medicines-07-00047.pdf and https://pubmed.ncbi.nlm.nih.gov/26964971/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921197/pdf/main.pdf

See the extensive clinical monograph on Phytolacca in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 795-798.

Phytolacca in King’s American Dispensatory, the standard Eclectic medical publication of 1898 https://www.henriettes-herb.com/eclectic/kings/phytolacca.html

Ruth Trickey (with practitioners from the Melbourne Holistic Health Group), respected midwife and herbalist, mentions the use of Poke for mastalgia in her classic Women, Hormones & the Menstrual Cycle, 3rd Ed., Trickey Enterprises (Victoria) Pty, Limited; 2011.

Bioactive triterpene saponins from Phytolacca americana https://pubmed.ncbi.nlm.nih.gov/33002830/

Dr. Aviva Romm mentions topical Phytolacca for benign breast disease in Botanical Medicine for Women’s Health (p. 595), Churchill Livingstone; 2nd Ed.; 2017.

Effective medicinal plants for cyclic mastalgia, a review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820470/

Topical application of St. John’s Wort https://pubmed.ncbi.nlm.nih.gov/24214835/

Anti-inflammatory mechanisms of Hypericum oil https://pubmed.ncbi.nlm.nih.gov/24993886/

Cell-growth regulating effects of the oil-soluble constituents https://pubmed.ncbi.nlm.nih.gov/33379141/

See the extensive clinical monograph on Hypericum in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 826-860.

Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast Journal. 2009;15:510–4. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/19614907

American Herbal Pharmacopoeia (AHP) monograph on Trifolium http://pharmaguri.co.il/_Uploads/dbsAttachedFiles/AHPTrifoliumMonograph.pdf

Review – pharmacology of the main isoflavonoid in Trifolium, Biochanin A https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639423/pdf/fphar-10-00793.pdf

Trifolium’s potential as a complementary therapy in breast cancer (apoptotic, antioxidant, anti-inflammatory) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455927/

Pharmacological and therapeutic properties of Red Clover 2021 https://pubmed.ncbi.nlm.nih.gov/34392659/

Isoflavones (Trifolium constituent) and mastalgia, clinical trial https://pubmed.ncbi.nlm.nih.gov/14965665/

Clinical actions of Red Clover https://restorativemedicine.org/library/monographs/red-clover/

Anti-inflammatory activity of Andrographis and andrographolide https://pubmed.ncbi.nlm.nih.gov/25888070/

Anti-inflammatory diterpenoid lactones in Andrographis https://pubmed.ncbi.nlm.nih.gov/31357563/

Andrographis review: ethnobotany, phytochemistry, pharmacology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408759/pdf/TSWJ2014-274905.pdf

See the extensive clinical monograph on Andrographis in Principles and Practice of Phytotherapy, 2nd. Ed., Simon Mills & Kerry Bone. London, UK: Churchill Livingstone/Elsevier; 2013. Pp. 360-372.

See Discover Andrographis by Alexander Panossian, Ph.D. Detailed monograph/book. https://www.academia.edu/40480219/DISCOVER_ANDROGRAPHIS


Unfortunately, at this point we only ship to the United States. This is due to the ever-evolving international laws surrounding supplements.

There are forwarding companies like MyUS.com, that will forward orders to you in your country for a fee.

In this case, it is the customer's responsibility to find out in advance if the supplement in question is legal in their country. For example, Progesterone and DHEA are not legal to ship into Canada (Canada classifies bio-identical hormones as drugs so they can only be prescribed by a doctor or naturopath).

We have had customers successfully ship their supplements abroad using MyUS.com, however we have only limited experience with this service.


For small businesses like ours, the shipping fee covers the very real costs of getting your order to you: shipping, handling, packaging, warehousing, insurances, and fairly compensating all the people involved along the way. We do our best to keep this shipping cost as low as possible, and offer FREE shipping for orders $97 and above.


If you set up a subscription order and notice that you are being charged shipping, it could be due to one of these reasons:

1. Your order value is under $97

2. Your initial order qualifies for free shipping, but the order frequency on your subscriptions is different ( 1 product is set to ship every month, the other is set to ship every 2 months).

*The system automatically splits this kind of order into 2 separate shipments.

In this case it is more economical to set up one subscription every 2 months, and to increase your quantity to 2 units of the supplement that you consume monthly.

For example: 2 Vitamin B6 + 1 Essential Omegas every 2 months = free shipping.

Please email us at support@hormonesbalance.com if you would like some help managing your subscriptions.

How we make things to be delivered directly to you

Science. Research. Facts.

All our products are rooted in science. No BS, just clean and honest ingredients that work.

We don’t greenwash. Ever.

No greenwashing means that we don't use misleading marketing to make our products seem more green or eco-friendly. Our products really are as natural as it gets.

If it’s not squeaky clean, it’s out.

We work hard to bring you products that are safe and effective. The top offenders we never invite to the party: GMOs, hormone disruptors, gluten, soy, and dairy.

Rigorously tested

Our manufacturing facilities are GMP compliant, which means every product is carefully tested. Our products are proudly made in the US and Canada.

Time-honored traditions

Many of our products use botanicals inspired by ancient herbal traditions from around the world.

1+1 = 5

Our ingredients work synergistically, amplifying each other. We transform them into meaningful products that make a difference for your body and spirit.